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Chemotherapy CTradiation therapy RTand their combination are commonly prescribed for patients with cancer. These life-saving treatments, however, often cause systemic side effects including bone marrow suppression, immunosupression, nausea, vomiting, diarrhea, fever, anorexia, asthenia, cachexia, cardiovascular, renal and hepatic toxicity, alopecia, sloughing of skin and mucosal membranes related to its effects on rapidly mitotic cellular functionas well as central and peripheral neuropathic toxicities. Mucositis and peripheral polyneuropathy are amongst the most common painful side effects from these treatments, and will be the focus of this article.

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